Volume : 4, Issue : 1, January - 2015

Personalized therapy versus targeted therapy, differences in the meaning

Ma Gorzata Rogali Ska, Zofia M. Kilia Ska

Abstract :

<p>The diagnostics and treatment options for numerous cancers are improving and giving the opportunity for increase< /> disease curing efficacy. Unfortunately, the etiology of cancers&rsquo; transformation is still under investigations. Because of< /> a high number of diverse factors involved in cellular signal trafficking, as well as several metabolic pathways and their potential simultaneous< /> cross&ndash;reactivity, choosing the proper type of therapy based on expression of some common changes in marker profile characteristics for a< /> particular type of cancer could not be fully informative, especially for some patients who are resistant to the treatment. There is no doubt that< /> there is a need to transfer from trial&ndash;and&ndash;error medicine into directed and even more precise towards personalized medicine based on analysis< /> of parameters for a single patient in vivo and in vitro for checking before administration of the potentially effective type of drug(s) to avoid< /> application of ineffective therapy. In this review, we compare the differences between directed and personalized therapy based on our previous< /> studies on chronic lymphocytic leukemia cells versus chronic myelocytic leukemia treatment analysis related to aberrant activity of Bcr&ndash;Abl< /> kinase, which is an indication to tyrosine kinase inhibitor &ndash; Gleevec application. </p>